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- Document 2348
- DOCN M94A2348
- TI Verbal autopsy as a tool for assessing adult HIV-1 attributable
- mortality in a rural population.
- DT 9412
- AU Kamali A; Wagner HU; Kengeya Kayondo JF; Nakiyingi J; Mulder DW; Medical
- Research Council AIDS Programme, Entebbe, Uganda.
- SO Int Conf AIDS. 1994 Aug 7-12;10(1):324 (abstract no. PC0228). Unique
- Identifier : AIDSLINE ICA10/94370227
- AB OBJECTIVE: To validate the use of verbal autopsies (VA) for the
- assessment of HIV-1 attributable adult mortality in a rural population.
- METHODS: A rural population cohort was enrolled in 1989/90 through a
- census and serological survey, and kept under surveillance through
- annual surveys. In addition, a village based death registration was
- established. Sera were tested for HIV-1 antibodies using two independent
- EIA systems. A VA questionnaire based on the Bangui AIDS case definition
- was administered by paramedical staff within 4-12 weeks of death to
- relative(s) of the deceased. Assessment of the VA forms was done by 2
- clinicians who, unaware of HIV, status, independently indicated likely
- causes of death. The clinicians' assessments were categorised according
- to whether HIV was mentioned as the likely cause of death. RESULTS: The
- HIV-1 seroprevalence rate in adults (13+ yrs) was 8%. VA assessement are
- available for 154 deaths: 76 seropositives (SP) and 78 seronegatives
- (SN) deaths. Of these, 82 (61 SP; 21 SN) were aged 13-44 years. In 83%
- of SP and 13% of SN the death was attributed to HIV-1. Agreement between
- the assessors was high. The table shows the specificity and positive
- predictive value (PPV) for the age groups 13-44 and 45+. Also shown are
- attributable mortality fractions (AMF) comparing estimates based on the
- use of VA with those from the general cohort surveillance. TABULAR DATA,
- SEE ABSTRACT VOLUME. CONCLUSION: Comparison of the surveillance and VA
- based HIV-1 AMFs suggests that VA is a useful tool to estimate, at low
- cost, the HIV-1 AMF among adults in populations with a prevalence rate
- of 8% or more.
- DE Adolescence Adult Autopsy/*METHODS *Cause of Death Cohort Studies
- Human HIV Infections/*MORTALITY HIV Seroprevalence/TRENDS *HIV-1
- Middle Age Population Surveillance Rural Population/*STATISTICS &
- NUMER DATA Truth Disclosure Uganda/EPIDEMIOLOGY MEETING ABSTRACT
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
-
-